Ali MacGraw and Robert Evans were only a few years into their marriage when things took an unfortunate turn. The actress was cast in the thriller, “The Getaway,” where she connected with her heartthrob co-star Steve McQueen.
It was common knowledge that the actor was known for enjoying the company of women, and his charm managed to work on Ali as well. She parted ways with Evans in 1972 and married McQueen a year later, although the relationship ended five years later.
You, Me and Dupree
When Kate Hudson was cast to star in the comedy, "You, Me, and Dupree," she had been married to Chris Robinson for more quite some time. Sadly, their marriage face issue when the actress grew closer and closer to her co-star, Owen Wilson.
Hudson allegedly ended her marriage for the actor, which may not have been the smartest idea seeing as the actors' relationship was short-lived...
Woman of the Year
Unlike almost all the relationships on this list, Spencer and Louise didn't split up because of a film. They did, however, face a relationship altering affair on the set of "Woman of the Year." Spencer appeared in the movie with Katharine Hepburn, and from that moment on, his relationship with Louise was never the same.
The actor engaged in an affair with Hepburn that lasted for decades. Though the passion between Spencer and Katharine was undeniable, Louise didn't let that end her marriage, and the two stayed together until she passed in 1983.
Made In America
It's rare to see high school sweethearts make it in Hollywood; it's rare to see any couple make it in Hollywood for that matter. Ted Danson and Cassandra Coates were each other's sweethearts for more than a decade - they thought they were going to beat the odds.
Unfortunately, their devotion wasn't destined to last, and it came to an end when Danson appeared in "Made in America." Danson and Whoopi Goldberg's chemistry on set was inevitable and came at the expense of Ted and Cassandra's marriage.
The Last Picture Show
Peter Bogdanovich was sure he had devoted his life to his wife of nearly a decade, Polly Platt. That was until he met Cybill Shepherd. The director cast Shepherd in his drama, "The Last Picture Show," and sparks flew between the two.
He decided to leave his wife for Shepherd, and the two were in what most would call a successful Hollywood relationship. They eventually called it quits in 1978.